Prophet Muhammad (s) was born in 570 CE in Makkah (Bakka, Baca, Mecca). His father, Abdullah, died several weeks before his birth in Yathrib (Medinah) where he went to visit his father's maternal relatives. His mother died while on the return journey from Medinah at a place called Abwa when he was six years old. He was raised by his paternal grandfather 'Abd al Muttalib (Shaybah) until the age of eight, and after his grandfather's death by Abu Talib, his paternal uncle. 'Abd al Muttalib's mother, Salma, was a native of Medinah and he was born and raised as a young boy in Medinah before his uncle Muttalib brought him to Makkah to succeed him. Many years before Muhammad's birth, 'Abd al Muttalib had established himself as an influential leader of the Arab tribe Quraish in Makkah and took care of the Holy sanctuary Ka'bah. Makkah was a city state well connected to the caravan routes to Syria and Egypt in the north and northwest and Yemen in the south. Muhammad was a descendant of Prophet Ismail through the lineage of his second son Kedar.

The birth of Huzoor Ghaus-e-Azam (Radiallahu Ta'ala Anh) was a great blessing to the Ummah. It was the arrival of Sultanul Awliya (King of the Awliya), which had been foretold for centuries before his birth. He was born on the eve of the 1st of Ramadaan 470 Hijri in the city of Jilan and was blessed to his mother at an age when women are usually unable to have children. Sayyida Ummul Khair Fatima (Radiallahu Ta'ala Anha) was sixty years old when (Sarkaar-e-Ghaus-e-Azam Radiallahu Ta'ala Anh) was born. This alone was one of the astonishing incidents related to the birth of the great saint.

Khwaja Moinuddin Chisty (R.A.) was born in Seistan (East Persia) also known as Sejistan, around 537 Hijri in a respected family. His father Khwaja Ghayasuddin (R.A.) and mother Syeda Bibi Ummalwara alias Bibi Mahe-Noor were the descendants of Hazrat Ali (R.A.) through his sons Imam Hassan and Imam Hussain, Khwaja Saheb lost both his Father and Mother at an early age of sixteen years.